KETAMINE (INTRANASAL ESKETAMINE) Intranasal Spray is indicated, in conjunction with an oral antidepressant, for the treatment of: **Treatment-resistant depression (TRD) in adults. **Depressive symptoms in adults with major depressive disorder (MDD) with acute suicidal ideation or behavior. SPRAVATO (esketamine) is the first and only NMDA receptor antagonist approved for 2 subtypes of MDD in adult patients. SPRAVATO treatment is covered by most insurance companies.
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